Tell your doctor if you think you may take recreational drugs while you’re on tramadol. Talk to your doctor or pharmacist if you’re unsure whether it’s safe for you to drive while taking tramadol. Drinking alcohol while you’re taking tramadol can make you feel more sleepy or increase the risk of serious side effects. Stop drinking alcohol during the first few days of treatment until you see how the medicine affects you. If tramadol doesn’t get rid of your pain or works less well, talk to your doctor.